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designed a study that used a mouse model of maternal insulin deficiency induced by STZ (a pancreatic -cell toxin) injections during pregnancy to study the effects of maternal hyperglycemia on offspring [66]

There are three nose-to-brain pathways: (1) Olfactory nerve-olfactory bulb-brain

Transpathology: molecular imaging-based pathology

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Abbreviations ABTS 2,2'azinobis(3ethylbenzothiazoline6sulfonic) acid AIDS acquired immunodeficiency syndrome ALP alkaline phosphatase ALT alanine transaminase AMPK AMPactivated protein kinase AST aspartate transferase C3 carbon 3 CAT catalase CCL4 carbon tetrachloride CD4 cluster of differentiation 4 CMC carboxy methyl cellulose CuO NPs copper oxide nanoparticles DPPH 2,2diphenyl1picrylhydrazyl ESR1 estrogen receptor 1 FRAP ferric reducing antioxidant power GABA gammaAminobutyric acid GAE gallic acid equivalents GSH glutathione HCT hematocrit HDL high density lipoprotein HER2 human epidermal growth factor receptor 2 HIV human immunodeficiency virus IgE immunoglobulin E IL6 interleukin 6 LD lethal dose LDL low density lipoprotein MCF Michigan Cancer Foundation MDA malondialdehyde MIC minimum inhibitory concentration MPO myeloperoxidase MTT 3 (4,5dimethylthiazol2yl)2,5diphenyltetrazolium bromide NO nitric oxide PDB protein data bank PPAR peroxisome proliferatoractivated receptor gamma PRISMA Preferred Reporting Items for Systematic reviews and MetaAnalyses ROS's reactive oxygen species SOD superoxide dismutase SREBP1c Sterol regulatory element binding protein1c TC total cholesterol TFC total flavonoid content TG triglyceride TNF tumor necrosis factor alpha TPC total phenolic content VLDL very lowdensity lipoprotein 1