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Description

Hudnell HK et al

Recognising these interconnected symptoms enables timely intervention before deficiency leads to permanent damage

& Nicolls, M

doi: 10.1515/BC.2000.107 84 CroteauWDaveyJCGaltonVASt GermainDL

Together they reduce binding affinity to the six IGF binding proteins (IGFBP-1 through IGFBP-6) by approximately one to two orders of magnitude, while preserving full agonist activity at the type 1 IGF receptor