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88 In terms of immune regulation, it has been documented that interleukin-4 (IL-4) and IL-13 inhibit the expression of GPX4 in some tissues (including heart, spleen, lung, and kidney), while the expression of ALOX15 increases, resulting in the massive production of arachidonic acid metabolites and inducing lipid peroxidation

This evidence substantiates the proposition that GpoA operates within a H 2 O 2 detoxification pathway in S

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Sampson HA, Shreffler WG, Yang WH, Sussman GL, Brown-Whitehorn TF, Nadeau KC, Cheema AS, Leonard SA, Pongracic JA, Sauvage-Delebarre C, Assaad AH, de Blay F, Bird JA, Tilles SA, Boralevi F, Bourrier T, Hbert J, Green TD, Gerth van Wijk R, Knulst AC, Kanny G, Schneider LC, Kowalski ML, Dupont C (2017) Effect of varying doses of Epicutaneous immunotherapy vs placebo on reaction to peanut protein exposure among patients with peanut sensitivity: a randomized clinical trial