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Estudos in vivo podem incorporar amostragem ao longo do tempo para avaliar as relaes de exposio-resposta para marcadores moleculares selecionados, bem como medies em nvel tecidual em depsitos de tecido adiposo e rgos metabolicamente relevantes para caracterizar a distribuio de vias e as assinaturas de sinalizao subsequentes

They may arrange blood tests to evaluate: Inflammatory markers (ESR, CRP) to detect active inflammation Rheumatoid factor and anti-CCP antibodies if inflammatory arthritis is suspected Full blood count to assess haematological response to B12 treatment Thyroid function tests , as thyroid disorders commonly coexist with B12 deficiency Note that serum B12 levels are not typically measured to assess treatment adequacy once replacement therapy has begun, as they may not reliably reflect tissue stores

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