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Approximately 90 to 95% of circulating cortisol in plasma is found bound to proteins that make it unavailable for biological activity (Hellhammer et al., 2009)

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Arslan G, Atasever T, Cindoruk M, Yildirim IS

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The genes activated by the Nrf2/ARE pathway are responsible for producing Phase II liver detoxification enzymes and powerful endogenous antioxidants

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