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doi: 10.3897/pharmacia.71.e112322 109

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

However, the precise mechanistic pathway by which SLC 25A1 deregulation facilitates 2HG magnification and oncogenic transformation remains incompletely understood, warranting further investigation