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Limitations and Research Status While preclinical data is extensive, large-scale human clinical trials are limited

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27 Remarkably, rapid ascent to 4500 or 5500 m significantly increases HAPE incidence compared with slow ascent (0.2% versus 7% or 2.5% versus 15.5%, respectively), with a recurrence risk of ~60% under rapid ascent conditions

The incidence of erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis