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Taken together, all these results indicate that the newly identified spherical vesicles, with diameters ranging from approximately 3050 nm, may serve in plant retrograde transport and are distinct from the tubular recycling endosomes described in animal systems

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Class B GPCR Architecture and the Peptide Paradigm Understanding why orforglipron's mechanism is significant requires an appreciation of the GLP-1 receptor's molecular architecture and the historical challenges of targeting class B GPCRs with small molecules

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