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From a therapeutic perspective, targeting iron-dependent redox pathways offers multiple intervention points

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

Respiratory system : Succinate accumulation and TLR4/ROS signaling promote acute lung injury/acute respiratory distress syndrome (ALI/ARDS) through cytokine storm and alveolar damage

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Various studies have demonstrated that patients suffering from diabetes, severe obesity, hypertension and cardiovascular disease are more prone to experiencing unfavorable outcomes following infection with COVID-19 ( 3 Pathogenesis of septic ARDS Sepsis is the most common pathogenic factor of ARDS, which can cause ARDS in less than a week, and the prognosis of those patients is poor ( Figure 1 )