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doi: 10.1016/j.cmet.2019.11.010 86 PabstTKortzLFiedlerGMCeglarekUIdleJRBeyogluD

At the end of treatment, in those who received the n-3 PUFA, the plasma levels of DHA and EPA levels increased

The results indicated that metformin activated guanosine 5-triphosphate cyclohydrolase 1 (GTPCH1), leading to the recoupling of endothelial nitric oxide synthase (eNOS)