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CM-101 is currently being evaluated in a PSC phase 2 study

doi: 10.1038/s41591-018-0004-z, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Wang C., Xiong M., Gratuze M., Bao X., Shi Y., Andhey P

Ice nucleation activity in the widespread soil fungus Mortierella alpina

Acta 85 NishiokuT.DohguS.TakataF.EtoT.IshikawaN.KodamaK.et al (2009)

Here we investigated the potential interactions between APR-246/MQ and Trx1 and Grx1, and found that reaction of MQ with both Trx1 and Grx1 was associated with loss of free thiols in both proteins