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Statements Author contributions The authors had an equal contribution in the writing of the manuscript (IL, AG and AE)

In the RCTs, prebiotics showed similar clinical efficacy to mesalamine, and synbiotics, combined with probiotics and prebiotics, could also significantly decrease the CAI, the levels of intestinal mucosal inflammatory cytokines and fecal calprotectin, but not DAI [308,309,310,311,312]