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For histone acid extraction, cells were lysed in hypotonic lysis buffer (10 mM Tris-HCL pH 8, 1 mM KCL, 1,5 mM MgCl 2 , 0,1% Triton X-100 and 1X protease inhibitor cocktail) and incubated for 30 min on a rotator at 4C

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