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These inhibitors not only prevent necroptotic cell death but also play a crucial role in suppressing NLRP3 inflammasome activation, thereby reducing neuroinflammation and neuronal damage in models of glutamate-induced excitotoxicity (113)

The catalytic parameters and substrate specificity of GPx6 are not known as the protein has not been purified yet [1, 8]

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Secondary oxidative stress is a common occurrence in disease, often reducing the efficacy of standalone antioxidant therapies

113,114 Wnt/-catenin pathway in other cardiovascular diseases LRP5 regulates body fat distribution through the canonical Wnt signalling pathway and affects the occurrence of cardiometabolic disorders, which is consistent with the increased prevalence of cardiovascular disease in subjects with abdominal obesity