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There is abundant evidence of adverse health effects in all of these populations

In respect to vesicular release, it appears unlikely that filling of vesicles with ATP by VNUT is regulated by [ATP] c (at least for the physiological concentration range), given that VNUT is an active transporter and [ATP] c is rather high

doi: 10.1016/S2213-2600(22)00159-X 177 OMahoneyLLRoutenAGilliesCEkezieWWelfordAZhangAet al

Von Frey test We assessed mechanical pain sensitivity by observing the paw withdrawal reaction to von Frey filament stimulation

Firstly, combination therapy: The synergistic effects of combining these ESCM with conventional treatments (e.g., chemotherapy, radiotherapy, immunotherapy) should be investigated to enhance therapeutic efficacy and mitigate side effects