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Patients can be directed to administer a defined number of sprays per nostril at specified times typically once or twice daily, often timed to evening or pre-sleep for alignment with endogenous GH pulse patterns

Because the tunnel has limited room, even modest swelling may increase pressure around the nerve

One study noted that ghrelin may upregulate cartilage-specific genes, and another noted that ghrelin may help mesenchymal stem cells (universal stem cells that can differentiate based on need) to target cartilage repair [9, 10]

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[PubMed: 23939956] 94