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Lipid peroxidation damages cell membranes and generates diffusible aldehydic by-products, including 4-hydroxynonenal (HNE) and 4-hydroxyhexenal (HHE)

A multicenter phase II study of the efficacy and safety of quisinostat (an HDAC inhibitor) in combination with paclitaxel and carboplatin chemotherapy (CT) in patients (pts) with recurrent platinum resistant high grade serous epithelial ovarian, primarily peritoneal or fallopian tube carcinoma cancer (OC)