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Traditionally, macrophages can be polarized into two distinct phenotypes, namely classically activated M1 macrophages and alternatively activated M2 macrophages (23)

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Therefore, the hypothesis to be tested is whether Lurcher mice could be considered as a model for combined cerebellar motor syndrome and CCAS

For example, glomerular endothelial cells, podocytes, or tubular epithelial cellsall involved in IgA nephropathy pathogenesismay also undergo ferroptosis or modulate mesangial cell ferroptosis via paracrine signaling, yet their roles in amplifying renal injury remain unaddressed