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reported that avicularin can exert a protective effect against ALF by activating the classic Nrf2/HMOX1/glutathione peroxidase 4 (GPX4) antioxidant stress pathway[3]

134 MoriyaJ.ChenR.YamakawaJ.SasakiK.IshigakiY.TakahashiT

Regeneration of other antioxidants When an antioxidant scavenges a free radical, it becomes oxidized itself and is not able to scavenge additional ROS or RNS until it has been reduced

Even though ethanol extracts are the most used to produce tablets and other galenic preparations, comparison studies among the various types of preparations, like the essential oil and the oily macerate, have not yet revealed which are most effective and which active constituents are the most important [132]