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Nestin and SOX2 are embryologic stem cell transcription factors that bind an enhancer region on the nestin gene, and they are preferentially co-expressed in metastatic melanomas when compared with nevi or primary melanomas

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The peptide's primary function may not ultimately be sleep at all, although it is most closely associated with sleep cycle regulation, because DSIP levels are the same in CNS tissues as in peripheral tissues, suggesting that the peptide may also be formed outside the CNS

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