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PI3K signaling pathway in neutrophils The PI3K pathway has been identified as a major signaling pathway in the downstream signaling cascade of GPCRs within neutrophils 17,145,382 (Fig

Compounds targeting CFTR protein trafficking: CFTR correctors The F508del-CFTR mutant is a misfolded thermo-instable protein that undergoes premature intracellular degradation and can be rescued at the cell surface in vitro by culture of cells at low (2630 C) temperature