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Epub 2020 Jul 10

Some views suggest that Thyroid Stimulating Hormone (TSH) stimulation or neoplastic transformation of Hrthle cells may be responsible for the development of carcinoma in HT

The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison

Chronic chemical exposure should be curtailed as much as possible

This is consistent with previous findings that -cell plasticity occurs in common forms of -cell dysfunction, and is caused by the downregulation of FoxO1 that follows hyperglycemia-induced oxidative stress 26