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Furthermore, anticholinergic medications, such as trihexyphenidyl, are used also in PD management but struggle to effectively cross the BBB and often exhibit non-specific binding, leading to undesirable peripheral effects such as dry mouth and cognitive impairment, particularly in elderly patients

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More recent research has identified the major site(s) of superoxide generation within mitochondria and it is generally agreed that complexes I and III of the electron transport chain are the primary locations of mitochondrial superoxide production (44, 277)

The skin-tone effect builds over weeks and requires consistent sessions to maintain