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Early evidence for the potential efficacy of this route was published in 1999, where 18 patients with B12 deficiency treated exclusively with 712 days of 2 mg of sublingual cobalamin daily had 4 times higher B12 levels compared to pre-treatment, reaching therapeutic ranges ( There have also been further studies comparing treatment outcomes from the sublingual route to the more established IM and oral routes

Regular B12 injections can help combat fatigue, improve mood, and support overall metabolic functions

This prevents condensation from forming inside the vial

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The low haptocorrin in the blood results in low serum B12 levels without a functional deficiency (Carmel, 2009)