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Moore JB (2019) From sugar to liver fat and public health: systems biology driven studies in understanding non-alcoholic fatty liver disease pathogenesis

These findings highlight the regulatory potential of circRNAs in MSC stemness and their promise as therapeutic targets for bone regeneration

Because the histone H3K27 methyltransferase EZH2 has a higher affinity for SAM (with a lower Km value) than the H3K4 methyltransferase MLL1, under conditions of limited SAM availability, EZH2 can utilize the substrate more efficiently and maintain its activity relatively well, whereas MLL1 activity is more severely suppressed (51)

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