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In a mouse model of SCA6, BDNF and TrkB were downregulated at the age-at-onset, and early activation of TrkB-AKT signalling improved symptoms 59 , supporting our previously unappreciated findings whereby early manipulation of TrkB signalling regulated pathways in which GSH metabolism is crucial to halt the degenerative process triggered in iSPNs lacking BDNF-TrkB signalling

Both are due to autoantibodies which affect the function of the thyroid gland

After 20 min, the collagenase solution was removed by straining samples through a 100 M cell strainer, and tumour tissues were again digested for an additional 20 min

Quantification was performed using multinotch SPS-MS3 (66)

NOX5 is highly expressed in the lymphoid tissue and the testis