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Humane endpoints were predefined, and any animal exhibiting severe distress would have been immediately euthanized to minimize suffering

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Several other drug-like molecules have been shown to negatively affect the interaction of SOD1 with hCCS 20

Regulating astrocytes associated with neurexins Previous studies have found that astrocyte contact with neurons can alter the localization of neurexins at synapses, while the expression of neurexins at dendrites can also provide negative feedback on the increase in synapses mediated by astrocyte contact [88]