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10.1097/ICO.0b013e318299549c 168 SherrattS

Stupnisek M, Franjic S, Drmic D, Hrelec M, Kolenc D, Radic B, et al

To mitigate acute arthritis attacks and associated complications, early initiation of pharmacotherapeutic interventions is advisable

This has been overcome through various methods that favor the intramolecular reaction over the intermolecular variant, such as selection of reactive amino acid positioning in relation to the linker or preorganization of the peptide chain