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Nat Chem Biol 7 , 885887 (2011)

Cancer 82, 19071913

In addition, enhanced GCase expression stimulates the lysosomal degradation of -synuclein

For that reason, successful management requires not only targeting the damaged nerve, but also understanding the broader neurological and systemic context in which pain persists

Current research suggests that in macrophagesespecially under conditions of impaired phagolysosome function, altered heme transport activity, and oxidative stressHO-1 may shift from a cytoprotective to a cytotoxic role