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doi: 10.1016/j.redox.2020.101435 204 ZhaoCTangZYanJFangJWangHCaiZ

It has been established that several mechanisms may contribute to the dysfunction of HBV-specific T cells, such as continuously high viral load and high antigen levels, suppressive cytokines including interleukin-10 (IL-10) and transforming growth factor- (TGF- ), dendritic cells (DCs) and regulatory T (Treg) cells, which were able to result in a progressive loss of T-cell function and cause HBV-specific T cells to become exhausted 7, 8 (Figure 1)

Additionally, treatments such as Microbiota Transfer Therapy (MTT), focused on gut microbiota regulation, have shown promising results by improving ASD-related symptoms in patients that were sustained after finishing the treatment (Kang et al., 2019)

NTR1 activation enhances neuronal excitability and improves spatial learning ability and memory in APP/PS1 transgenic mice [66]

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