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10.1634/stemcells.2007-0509 14 ClarkJ.SimonD

Proteomics 13, 2031204510.1002/pmic.201200479 16 TorresM

They dramatically reduce its affinity for insulin-like growth factor-binding proteins (IGFBPs), which normally sequester IGF-1 in the bloodstream and limit its activity

One of the patient's main complaints was back pain when trying to straighten up, limited mobility in large joints (shoulder, knee, hip)

Ascorbic acid, the active form of Vit C, can increase FR production when it interacts with metals such as iron and copper, as it has the ability to reduce Fe 3+ and Cu 2+ to Fe 2+ and Cu + [296]