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The immunochemical staining and statistical analysis indicated an upregulated REST expression level in ATN, which was positively correlated with the markers of kidney injury, Scr and BUN (Figure 1, AC)

doi: 10.1038/s41590-019-0388-z 29 OSullivanTEJohnsonLRKangHHSunJC

Considering the above, it appears reasonable to include substances that would not only restore normal glycemia and tissue sensitivity to insulin but also positively affect mitochondrial functions at the stage of hyperglycemia

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Li Q, Chen J, Ren Y, Yang Z, Wang M, Zhang W et al (2024) Protective effects and mechanisms of luteolin against acute respiratory distress syndrome: network pharmacology and in vivo and in vitro studies