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These drugs are commonly referred to as biased ligands. For instance, G protein-biased -opioid receptor (OR) agonists are of remarkable clinical relevance as they enhance analgesia effects and reduce adverse reactions associated with the activation of -arrestin pathways, in contrast to morphine

It dissolves well in DMSO at 1mg/ml However, adding water may cause cloudiness In that case, applying ultrasonic treatment for 2 seconds usually clears the solution Consequently , proper handling ensures accurate experimental results and consistent performance

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Accordingly , these activities do not include clinical, cosmetic, therapeutic, or diagnostic use