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Importantly, BPC-157 shows no direct angiogenic effect on endothelial cell cultures, suggesting its pro-angiogenic activity requires the context of injury and healing responses present in vivoa safety feature that may limit unwanted neovascularization in healthy tissues

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Prescribers should re-evaluate the evidence base at least every 6 to 12 months, as a single well-designed Phase II trial could substantially shift the risk-benefit calculus for BPC-157 in GI healing