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Abnormal iron metabolism and mitochondrial dysfunction are the pathologic and cytologic basis of the disease, and the cerebellum, heart, and spine are the main affected tissues [4,5,6]

Electrolytes, urea and creatinine (EUC) should be ordered to exclude clinically significant kidney disease, and a pregnancy test should be ordered in premenopausal women

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Biologically, GPx distribution varies across compartments: erythrocytes exhibit significant GPx1 activity for hemoglobin and membrane protection (Ravn-Haren et al., 2006)

Chem Phys Lipids 79:157163 Chen J, Lindmark-Mansson H, Gorton L, Akesson B (2003a) Antioxidant capacity of bovine milk as assayed by spectrophotometric and amperometric methods