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For example, APR-246 works by reducing intracellular glutathione levels and increasing reactive oxygen species (ROS) levels, but this mechanism may be affected by other metabolic pathways within the cell

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Finally, we did not measure the severity of patients psychiatric diseases during the assessment

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The ARE is a vital component of the promoter regions of genes encoding detoxifying, antioxidant, and glutathione-regulatory enzymes such as quinone-reductase, glutathione-peroxidases, glutathione-reductase, thioredoxins and thioredoxin-reductase, peroxiredoxins, gamma-glutamyl cysteine, heme-oxygenase-1 (HO-1), CAT, SOD metallothionein and ferritin [64-67]