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Methods: DATA were enrolled from the Alzheimers Disease Neuroimaging Initiative (ADNI) database, and we studied healthy individuals (as controls, a total of 54), patients with mild cognitive impairment (345), and patients with Alzheimers disease (96) A one-year follow-up was conducted to collect data on the dynamic changes of GST protein levels in plasma and primary information data, and to analyze the correlation between the changes in GST protein levels before and after the follow-up and cognitive function and its predictive value