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ATO induces significant oxidative DNA damage in normal skin fibroblasts, triggering the ATM- Ataxia-Telangiectasia and Rad3-Related (ATR)-Chk checkpoint pathway and leading to cell cycle arrest [316]

Functionally, glutamine plays a vital role as a nitrogen transporter, aiding in the transfer of nitrogen generated in tissues to the kidneys for excretion, including the nitrogen released by skeletal muscles, with more than 80% of it being transported through glutamine [126, 127]

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Acquired Abnormality of Cobalamin Metabolism: Nitrous Oxide Inhalation Nitrous oxide (N 2 O) irreversibly oxidizes methylcobalamin to an inactive precursor

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