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Incubation of acetone with homogenates of nasal mucosa from mice indicated that acetone was metabolized via a NADPH-dependent pathway in vitro , but no evidence of in vivo metabolism of acetone by the upper respiratory tract was found in mice, rats, guinea-pigs or hamsters (Morris, 1991 )

Additionally, MRP2 contains a 100-residue long linker between NBD1 and TMD2, resembling the regulatory (R) domain of the cystic fibrosis transmembrane regulator (CFTR)

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Since cancer is widely recognized as an age-related disease and the incidence of most cancers increases with age 77 , the roles of SIRT7 in cancers should be clearly elucidated if considering its further therapeutic application for aging