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ZnO nanoparticle treatment activates the autophagy pathway, inducing ferritin degradation in a nuclear receptor coactivator 4 (NCOA4)-dependent manner, leading to Fe 2+ overload and ferroptosis [55]

Personalizing treatment is paramountwhat works wonderfully for one person may not be suitable for another

Balakrishnan V, Pillai MV, Raveendran PM, Nair CS

[2] However, once stores are depleted, symptoms can include fatigue, weakness, constipation, loss of appetite, and neurological changes such as numbness, tingling, balance problems, and cognitive difficulties

Firstly, ASCL1-dominant SCLCs are more susceptible to complex I inhibition along with CPT1 inhibition