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By western blot analysis, we still found a large amount of p--syn in the hippocampal tissues of reoxygenated mice, suggesting that -syn pathology induced by chronic hypoxia was also irreversible for an extended period of time (Fig

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Mechanistically, it has been observed that GSTP1-1 binds, in its monomeric form, both c-Jun and JNK, thus forming an heterotrimeric complex that inhibits the phosphorylation of c-Jun by JNK