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While both compounds demonstrate remarkable individual efficacy and work through complementary mechanisms that theoretically could synergize, the complete absence of clinical trial data makes any combination approach purely experimental

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Amorphous solid dispersions, while improving solubility, have a natural tendency to transform into a more stable crystalline form over time, which can lead to a loss of the bioavailability benefit (153)

For instance, deletion of one SOD allele in transgenic mice over-expressing -APP accelerated the onset of behavioural changes and A plaques in brain parenchyma, but increased the development of cerebrovascular amyloidosis, gliosis, and neuritic dystrophy

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