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However, in contrast to other anxiolytics such as benzodiazepines, somatostatin exerts pro-cognitive effects under healthy (Liguz-Lecznar et al., 2016) and Alzheimer's disease conditions (Epelbaum et al., Response to stress Activation of CRF signaling CRF expression is upregulated in the hypothalamus and the peptide released into the median eminence under conditions of stress leading to pituitary ACTH and subsequently adrenal glucocorticoid hormone release (cortisol in humans and corticosterone in rodents) (Turnbull and Rivier, 1997

Theca cells are very sensitive to the gonadal steroid gonadotropin, which cause hyperandrogenism in PCOS patients (56)

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