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Because elevated homocysteine can be caused by a number of factors [68] and enzymatic confirmation of CBS deficiency is available in only a few laboratories worldwide, functional information from the VE map could enable clinical interpretation of pathogenicity and thus aid in clinical diagnosis

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It concurrently suppresses mRNA expression of cannabinoid receptor type 1 (CB1), further consolidating its protective effects along the gut-liver axis ( Supplementation with RSV (50/75/100 mg/kg/d) significantly reduced hepatic steatosis and fibrosis in HFD-induced NASH rats, with the ameliorative effect demonstrating dose dependency