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The main factor influencing the extentof pathogen reduction is the chlorine dosethe product of the residual chlorine concentration (C) and the contact time (T) (i.e., the CT value)

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In parallel, Liu and colleagues demonstrated that the immunomodulatory effects of IVIg were dependent on FcRn, as they found that both experimental induction of Ab-driven autoimmune diseases and IVIg-mediated protection against the diseases were manifested in WT, but not in FcRn-deficient mice [116]

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