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This reduction was driven primarily by a significant decrease in nonfatal stroke

However, there is a observational study that propose the opposite conclusion (23)

Summary Laryngopharyngeal reflux represents a common extraesophageal manifestation of gastroesophageal reflux, producing a range of upperairway and throat symptoms that require careful evaluation and integrated management to prevent chronic mucosal damage and functional impairment

Interleukin 6-mediated endothelial barrier disturbances can be attenuated by blockade of the IL6 receptor expressed in brain microvascular endothelial cells

Dispose of them after the suggested usage duration upon reconstitution