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This increased expression is correlated with rapid proliferation, but is inversely associated with cellular motility, including migration and invasion 164

Those observations suggested that the role of COX-1 in NAFLD is a subject of controversy, contingent upon complex molecular mechanisms influenced by functional cell types and extracellular stress

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Boelens PG, Houdijk AP, Fonk JC, Nijveldt RJ, Ferwerda CC, Von Blomberg-Van Der Flier BM, et al

found that the process of ferroptosis in RPECs triggered by SI is linked to the Nrf2/SLC7A11/HO-1 pathway