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The main characteristics of Mller cell gliosis are cell hypertrophy, with thickening of both somas and processes, proliferation, as well as increased expression of cytoskeleton constituent proteins such as vimentin or GFAP, and decreased expression of GS ( During gliosis, Mller cells will also contribute to the formation of glial scars, which can inhibit the remodeling and normal regeneration of damaged retinal tissue (Lu et al., 2011

Network plasticity and adaptation At the cellular level, the intrinsic redundancy of metabolic networks fuels adaptive resistance [268]

Injections may offer stronger, more consistent absorption, while oral drops provide a needle-free option that fits easily into daily routines

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