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A complicating factor in the concept of homosynaptic plasticity is the nature of input-specificity. Conventionally, plasticity is called input-specific if no changes are observed in an independent test input, not stimulated during the induction, i.e., no heterosynaptic changes

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The transamination reaction depends heavily on the conversion of pyridoxine, also known as pyridoxol and gravidox, to pyridoxal phosphate (PLP)

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Goldstein and colleagues described it as a component of the thymosin fraction from calf thymus, and later work demonstrated its ubiquitous expression in nucleated mammalian cells and high concentration in platelets [1]