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Since the inhibition of ASK1 (apoptosis signal-regulation kinase 1) in NLRP3 (NOD-like receptor thermal protein domain associated protein 3) mutant mice can reduce liver fibrosis, hepatocyte death, and liver TNF- expression, it suggests the application prospects of ASK1 inhibitor selonsertib in liver diseases

Woods PS, Kimmig LM, Meliton AY, Sun KA, Tian Y, O'Leary EM

Since some adverse effects such as serious infections and skin cancers were reported, additional evaluation of the safety profile of this drug is needed (Gordon 2012

ATG5-mediated keratinocyte ferroptosis promotes M1 polarization of macrophages to aggravate UVB-induced skin inflammation

Furthermore, the analog of -tocopherol, water-soluble vitamin E (Trolox), has been shown to reduce the hepatotoxicity of ATO while enhancing its anti-lymphoma effects